ABSTRACT

A precise, exact, cost effective technique for estimating Montelukast sodium and Bilastine simultaneously in several tablet definite volume has been evolved using the concept of simultaneous equation approach. Measurements of bilastine at 282 nm and montelukast at 344 nm in methanol form the basis of the approach. According to ICH guidelines, many analytical parameters including linearity, precision, accuracy, and toughness were determined. The concentration ranges of montelukast and bilastine, which are 2-12 g/ml and 4-24 g/ml, respectively, show linearity at their respective wavelengths. The method's validity was checked using statistics.The formulation of the analysis for montelukast and bilastine results expressed as a percentage of label claims were discovered to be 101.83% and 99.79%, respectively. The routine analysis of both medications can therefore be performed using the proposed approach.

Keywords: Montelukast Sodium, Bilastine, Simultaneous Equation Method