ABSTRACT

In the past few decades, 1,3-diaryltriazenes had been synthesized and investigated their biological and pharmacological profiles. 1,3-diaryltriazene compounds shows many activities like- anticancer, antioxidant, antimicrobial and anti-diabetic activities. The present study is focused on synthesis of novel series of 1,3-diaryltriazene derivatives from diazonium salt of sulfacetamide sodium and substituted aniline via continuous stirring at 0℃ temp. for 3 hrs. A different color of compounds is obtained and the five novel compounds are confirmed by spectral analysis of NMR, MASS spectroscopy and FTIR. Antioxidant activity of the newly synthesized compound have been investigated by many radical scavenging assays. Compound SSR1 (4-[3-(4-methylphenyl)-triaz-1-en-1-yl]-N-sulfanilyl acetamide sodium) and SSR5 (4-[3-(2-methylphenyl)-triaz-1-en-1-yl]-N-sulfanilyl acetamide sodium) have highest antioxidant potency presented (IC50 value are 241.70 and 256.37 µg/mL respectively for DPPH method. In NO(nitric oxide) radical scavenging assay, compound SSR1(4-[3-(4-methylphenyl)-triaz-1-en-1-yl]-N- sulfanilyl acetamide sodium) and SSR5(4-[3-(2-methylphenyl)-triaz-1-en-1-yl]-N- sulfanilyl acetamide sodium) have highest antioxidant value 75.80 % and 73.80 % respectively and reducing power antioxidant assay of the five compounds (SSR1-SSR5) were evaluated, compound SSR5 (4-[3-(2-methylphenyl)-triaz-1-en-1-yl]-N-sulfanilyl acetamide sodium) have highest antioxidant value.

Keywords: 1, 3-diaryltriazene, Antioxidant, Sulpha drug, Free radicals, Scavenging methods, Oxidative stress.